Pharmacokinetics: Absorption: After oral administration, phentermine is rapidly and completely absorbed from the gastrointestinal tract. Distribution: It is 17.5% bound to plasma proteins, reaching a peak concentration at 3-4.4 hours and its elimination half-life is approximately 20 hours. Metabolism: It is extensively metabolized via the liver through hydroxylation and oxidation, mainly by CYP3A4. Elimination: Phentermine is excreted primarily via the kidneys, with 62-85% of the drug being eliminated unchanged.
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